Warren Side Quest Eighteen: Terror Bus (III) – Infamous Guide – IGN

The Terror Bus has returned! If you’re going in the order we recommend, then you would have already encountered the Terror Bus side quest quandary twice before. But if not, let us fill you in. The Dustmen have taken control of a bus, armored it, and put a bunch of large machineguns on all sides of it. As it drives down the street, it shoots arbitrarily at everyone, and is obviously a dangerous menace to the innocent civilians of the borough of Warren. Making matters more complicated, a group of Dustman infantry is accompanying the bus. You’ll want to take care of them first, and then go after the bus itself.

Your best bet in dealing with the Dustman infantry is to draw them away from the bus in the opposite direction the bus is moving towards. This will keep you out of range of the dangerous weapons the bus has on it, and will allow you to accumulate some experience points from the Dustmen. Once the enemies are felled, the bus is moving around without protection, but it doesn’t exactly need any. Because the bus is so well-defended and tall, jumping atop it from the ground is nearly impossible. Instead, scale a nearby building and jump/fly onto the roof of the bus, where the engine of the vehicle can be discovered. Shoot it and destroy it, disabling the bus and ending this mission successfully.